| CAS Number | 77614-16-5 |
| Other Names | Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide |
| IUPAC Name | (2S)-N-[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide |
| Molecular Formula | C₄₀H₅₀N₈O₁₀ |
| Molecular Weight | 802.88 |
| Purity | ≥99% Pure (LC-MS) |
| Liquid Availability | N/A |
| Powder Availability | 10 milligrams vial (lyophilized/freeze-dried) |
| Storage Condition | Store cold, keep refrigerated. Do NOT freeze. |
| Terms | All products are for laboratory developmental research USE ONLY. Products are not for human consumption. |
**Important Information: Each peptide comes lyophilized/freeze-dried and must be reconstituted with Bacteriostatic Water in order to be dispensable in liquid form.
What is Dermorphin?
Dermorphin is a naturally occurring opioid peptide originally isolated from the secretions of South American Phyllomedusa tree frogs. Composed of seven amino acids, dermorphin is notable for its potent and selective agonist activity at the μ-opioid receptor, exhibiting strong analgesic effects at lower doses. Its unique structure featuring a D-alanine residue at the second position, confers enhanced receptor affinity and resistance to enzymatic degradation, distinguishing it from most endogenous opioids. Although primarily studied in experimental and pharmacological contexts, dermorphin has attracted interest for its potential therapeutic applications in pain management and neuroscience research.
Main Research
1) The presence of the N-terminal of the tripeptide dermorphin facilitates intrinsic opioid-like antinociceptive activity.
2) Dermorphin alleviates frostbite-induced pain through the regulation of TRP channel-mediated microglial activation and neuroinflammation.
Overall, the study demonstrates that DALDA exerts potent multimodal analgesic effects through peripheral MOR activation. Its actions include attenuation of thermal, mechanical, and cold hypersensitivity, reduction of oxidative stress, and suppression of inflammatory and nociceptive signaling in both the sciatic nerve and spinal cord. Together, these findings highlight the potential of DALDA to act as a promising therapeutic candidate for the management of frostbite-induced neuropathic pain and related inflammatory disorders [2].
Disclaimer
**LAB USE ONLY**
*This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
Citations
[1] Kisara K, Sakurada S, Sakurada T, et al. Dermorphin analogues containing D-kyotorphin: structure-antinociceptive relationships in mice. Br J Pharmacol. 1986;87(1):183-189. doi:10.1111/j.1476-5381.1986.tb10170.x [2] Ummadisetty O, Akhilesh, Gadepalli A, et al. Dermorphin [D-Arg2, Lys4] (1-4) Amide Alleviates Frostbite-Induced Pain by Regulating TRP Channel-Mediated Microglial Activation and Neuroinflammation. Mol Neurobiol. 2024;61(8):6089-6100. doi:10.1007/s12035-024-03949-4
Dermorphin is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.



