FOXO4 10mg*10vials

FOXO4-DRI (Proxofim) is a synthetic retro-inverso peptide studied extensively in laboratory research involving cellular senescence modulation, SASP regulation, and aging-related pathway investigation. As a compound of significant scientific interest, FOXO4-DRI is used by researchers investigating the fundamental mechanisms governing senescent cell biology, apoptotic pathway modulation, and tissue homeostasis in controlled experimental and preclinical model systems.

What Is FOXO4-DRI?

FOXO4-DRI is a synthetic peptide analog designed to interfere with the protein-protein interaction between FOXO4 and p53 within senescent cells, a pathway critical for senescent cell survival. In research settings, it is examined for its role in disrupting the pro-survival signaling that maintains senescent cells in a non-apoptotic state. Scientists study this compound to better understand how targeted disruption of specific protein interactions influences senescent cell fate decisions between quiescence, senescence, and apoptosis in laboratory models.

Structure and Function

FOXO4-DRI is a retro-inverso peptide stabilized through D-amino acid and reversed sequence engineering to resist proteolytic degradation. Its primary research function involves disrupting the FOXO4-p53 protein-protein interaction and examining downstream effects on senescent cell apoptotic signaling. Researchers also investigate its influence on the senescence-associated secretory phenotype (SASP) and tissue microenvironmental signaling, making it relevant to studies in gerontology, cellular biology, and aging pathway research.

Research Applications

FOXO4-DRI is of interest across several areas of scientific investigation, including:

• Cellular senescence modulation research studying senescent cell activity and SASP regulation in cultured cell lines
• Preclinical aging model investigation examining tissue function, metabolic health, and resilience in induced aging systems
• Signaling pathway elucidation using this peptide as a molecular tool to probe cell fate decision cascades
• Combinatorial therapeutic screening assessing synergy with other senomorphic or senolytic agents in controlled experimental settings
• Tissue homeostasis mechanism studies exploring targeted cellular clearance effects on regenerative capacity and organ microenvironmental signaling

Research Findings and Scientific Interest

Studies have examined the role of FOXO4-DRI in FOXO4-p53 pathway disruption, with findings pointing to its capacity to selectively promote apoptosis in senescent cells while sparing non-senescent populations in laboratory models. Research into its tissue homeostasis effects and aging pathway modulation continues to attract broad interest from the gerontology and cellular biology research communities. Its stable retro-inverso structure supports reproducible investigation across diverse senescence research experimental designs.

Availability and Specifications

FOXO4-DRI is available in lyophilized powder form at 10mg per vial, supplied as 10 vials per set, for use in controlled laboratory environments by qualified researchers.

This product is intended strictly for laboratory research purposes only. It is not intended for human consumption or for medical, veterinary, or therapeutic use.