Hexarelin is a synthetic hexapeptide belonging to the Growth Hormone Secretagogue (GHS) family. Structurally related to GHRP-6, it is chemically modified to enhance stability and potency. Preclinical research identifies Hexarelin as one of the most potent stimulators of Growth Hormone release available in the class, acting via the Ghrelin receptor (GHS-R1a) and potentially the CD36 receptor. Unlike other secretagogues, studies suggest Hexarelin retains efficacy even in the presence of somatostatin inhibition, though it is noted for inducing rapid receptor desensitization (tachyphylaxis) in long-term models. Supplied as a lyophilized powder strictly for laboratory research.
Area of Interest
Research on Hexarelin has focused on pituitary and cardiovascular pathways:
- Potent GH Secretion: Investigated for its ability to trigger massive, immediate pulses of Growth Hormone from the anterior pituitary, often exceeding the amplitude of GHRH stimulation alone.
- Cardioprotection (CD36 Pathway): Uniquely among GHS peptides, Hexarelin is studied for its binding affinity to the CD36 receptor in cardiac tissue, with research exploring potential protective effects against ischemic injury and cardiac fibrosis.
- Receptor Desensitization: A key subject in endocrinology research for studying the mechanisms of G-protein coupled receptor downregulation and physiological feedback loops.
- Musculoskeletal Recovery: Preclinical models examine its downstream influence on IGF-1 levels and nitrogen retention in skeletal muscle.
These properties make Hexarelin a primary reagent for laboratories investigating acute endocrine signaling and novel cardioprotective mechanisms.
Technical Information
- Chemical Name: Hexarelin Acetate
- Synonyms: Examorelin
- Molecular Formula: C₄₇H₅₈N₁₂O₆
- Molecular Weight: 887.0 g/mol
- Sequence: His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH2
- CAS Number: 140703-51-1
- Peptide Classification: Growth Hormone Secretagogue (GHRP)
Storage Guidelines
- Lyophilized peptide is stable at room temperature for several weeks.
- For long-term storage, keep at −20°C or below.
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Once reconstituted, store at 2–8 °C. Use within 3-4 weeks.
Solubility
Hexarelin is soluble in sterile water, saline, or bacteriostatic water.
References
- Arvat, E., et al. (1997). “Hexarelin, a synthetic growth hormone releasing peptide, shows no desensitization effect on GH secretion in humans after 8 days of administration.” Journal of Endocrinological Investigation (Contrasting acute vs chronic models).
- Locatelli, V., & Torsello, A. (2006). “Growth hormone secretagogues: focus on the growth hormone-releasing peptides.” Pharmacological Research, 54(6), 416-430. https://doi.org/10.1016/j.phrs.2006.07.011
- Mao, Y., et al. (2014). “Hexarelin treatment preserves heart function and remodeling after myocardial infarction.” Peptides, 56, 125-132 (Cardioprotective research). https://doi.org/10.1016/j.peptides.2014.04.004
Certificate of Analysis (COA): Available here
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